pentobarbital will lower the level or outcome of doxorubicin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will decrease the extent or influence of etonogestrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.Labor and delivery: Hypnotic doses of those barbiturates will not